Studies were carried out to examine the effects of long-term recombinant human growth hormone (GH) therapy on longevity in rodents. In the first study, 150 18-month-old female F344 rats were divided into three groups of 50 rats per group: Group 1, solvent vehicle; Group 2, 10 μg GH/kg body weight three times per week; Group 3, 50 μg GH/kg body weight three times per week. GH and solvent vehicle therapies were started at 18 months of age and continued until all the animals died spontaneously. Serum insulin-like growth factor (IGF)-I was measured at 18 and 29 months of age and on 3-month-old rats. Serum IGF-I level decreased between 3 and 29 months of age. GH therapy reversed the decrease in a dose-dependent manner, with the 50 μg GH dose returning the serum IGF-I level to that of 3-month-old animals. However, statistical analysis revealed no significant effect of GH therapy on median life span …

Total citationsCited by 32 19981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020Scholar articlesAged-rodent models of long-term growth hormone therapy: lack of deleterious effect on longevityDN Kalu, PB Orhii, C Chen, DY Lee, GB Hubbard… – The Journals of Gerontology Series A: Biological …, 1998Cited by 32 Related articles All 8 versions

Publication info:

  • Prof. Ibiyemi Olatunji
  • 1998/11/1
  • The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
  • B452-B463
  • 53


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