Streptozotocin diabetes and insulin resistance impairment of spermatogenesis in adult rat testis: central Vs local mechanism

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Mammalian reproduction is dynamically regulated by the pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones are synthesized in the pituitary gland following stimulation by the gonadotropin-releasing hormone (GnRH) and act by stimulating steroid production and gametogenesis in both males and females. Male adult Sprague-Dawley rats (120–140 g) were randomly divided into 7 groups. Group 1> Control group; fed on normal rat pellets. Group 2> Streptozotocin group; received a single dose IP injection of streptozotocin 45 mg/kg BW in Na+ citrate buffer pH 4.5. Group 3> Streptozotocin-insulin treated group; received a single dose IP injection of streptozotocin as in group 2 above and treated with insulin sub-cutaneously. Group 4> Streptozotocin-ginger treated group; received a single dose IP injection of streptozotocin as in group 2 above and treated with 500 mg/Kg Ginger extract orally. Group 5> Insulin resistant group; fed ad libitum on a special diet containing 25% fructose mixed with 75% normal rat chow (w/w). Group 6> Insulin resistant-pioglitazone treated group; fed ad libitum on a special diet as in group 5 above and treated with Pioglitazone 15 mg/kg orally. Group 7> Insulin resistant-ginger treated group; fed ad libitum on a special diet as in group 4 above, and also treated with 500 mg/Kg Ginger extract orally. Hormonal and tissue biochemistry analyses revealed that both central and local mechanisms are implicated in the impairment of spermatogenesis by diabetes but the hypothalamo-pituitary testicular axis alteration might not likely have a major impact as the local defect on …

Total citationsCited by 42 2013201420152016201720182019202020212022Scholar articlesStreptozotocin diabetes and insulin resistance impairment of spermatogenesis in adult rat testis: central Vs local mechanismAP Arikawe, A Oyerinde, II Olatunji-Bello, LFO Obika – Nigerian Journal of Physiological Sciences, 2012Cited by 42 Related articles All 10 versions

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